![]() ![]() We compared whole-tissues, ADSCs, and adipocytes from body mass index–matched lipedema ( n = 14) and unaffected ( n = 10) patients using comprehensive global lipidomic and metabolomic analyses, transcriptional profiling, and functional assays. To identify molecular mechanisms underpinning lipedema, we employed comprehensive omics-based comparative analyses of whole tissue, adipocyte precursors (adipose-derived stem cells (ADSCs)), and adipocytes from patients with or without lipedema. Lipedema, a poorly understood chronic disease of adipose hyper-deposition, is often mistaken for obesity and causes significant impairment to mobility and quality-of-life.
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